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This relates to situations where there are no significant risks from heat or any other heat sources. Protective clothing that complies with this standard is not suitable if additional protection is needed because of a risk from heat and flames. The standard also defines additional requirements for protective clothing, including mechanical requirements and requirements governing labeling and the supply of information from the manufacturer.

Protective clothing in accordance with EN ISO consists of several one or multi-layered garments or a single garment.

About testing procedures and fulfilling safety standards

Each material assembly is assigned to an index 1, 2 or 3 for limited flame spread in accordance with testing as per ISO DIN EN certified products. Standard DIN EN regulates the requirements for whole-body protective suits or full protection suits with sealed connections between different parts of the clothing if present.

Chemical protective clothing is essentially divided into categories according to specific applications. The test criteria for protective clothing against liquid chemicals can be proven using specific test methods. Jet test used for liquid-tight protective suits — type 3 For the jet test for liquid tight protective suits, the protective clothing is worn by a test person over an absorbent overall. The material undergoes predetermined stress testing while a specific volume of marker liquid is blown at the test person from a test apparatus using a strong air stream.

The liquid-tightness of the protective suit is determined via a visual inspection of the overall worn underneath. Spray test used for spray-tight protective suits — type 4 The functionality of type 4 spray-tight protective suits is tested by way of a liquid spray test.

The spray test is carried out in the same way as the jet test, with the difference that the marker liquid is blown from the test apparatus in bursts of finely atomised spray. EN certified products. The European standard ISO regulates the minimum requirements for type 5 chemical protection suites. This covers whole-body protective suits that protect the wearer against particles and aerosols of solid chemicals. The garments specified by the standard cover the torso, arms and legs with or without a hood or foot protection.

The particle-resistant chemical protective clothing must have resistant properties against the penetration of airborne solid particles in order to adequately protect the wearer. ISO 1 certified disposable protection. The standard's requirements include protection provided by special finishing of the fabric in combination with the required processing of the suit, particularly the seams. Test criteria for these requirements include resistance of the material against penetration by liquids, and resistance to penetration by sprays see spray test method.

Standard DIN EN regulates the minimum requirements for protective suits that are worn when handling or spraying pesticides and should protect the wearer from potential hazards when spreading such substances. The performance requirements for protective clothing against pesticides include regulations on the strength and impermeability of the material.

Protective Heat Heat Series Book 3 - omyhukocow.tk

Working with undiluted, concentrated pesticides also requires additional protective equipment such as aprons, special safety gloves for plant protection and face protection. The performance requirements and test methods for protective clothing against infectious agents are regulated in standard DIN EN Protective clothing tested in accordance with DIN EN guarantees resistance against the penetration of biologically contaminated liquids wet bacterial penetration.

The special requirements for clothing materials used to protect against infectious agents guarantee protection of the skin and the wearer from potential contact with biological substances, thus helping to prevent the spread of microbes. Protective suits certified in accordance with DIN EN can be identified by the biohazard pictogram.

Protective clothing and disposable coveralls

EN certified protective suits. Part 2 of standard DIN EN regulates the requirements and test methods for non-ventilated protective clothing against particulate radioactive contamination. Protective clothing in accordance with the standard should protect the wearer against radioactive contamination from solid particles.

The standard does not cover protection from ionising radiation, or protection of patients against contamination from radioactive substances used in diagnostic or therapeutic measures. The performance requirements for the protective clothing also demand that the garment is easy to put on and take off, and that the contamination risk is reduced to a minimum.

The protective clothing may consist of one part or of several parts that are put on together. Protective clothing in accordance with DIN EN must also be equipped with firmly and permanently attached accessories hood, gloves, galoshes, respiratory protection. Home Knowledge Safety standards Protective clothing and disposable overalls.

Protective clothing and disposable coveralls. About testing procedures and fulfilling safety standards Our textile testing lab in Ellefeld makes sure that our safety textiles fulfil and in most cases heavily exceed the necessary safety standards. Two performance parameters are specified for this protective clothing: Particular properties of the clothing therefore include: Part Test method DIN EN The test method of EN is based on determining surface resistivity in ohms the lower the resistivity, the faster the charges can flow.

The method can only be used on materials with a conductive surface, such as carbon or steel fibre. DIN EN EN defines the performance requirements for the material and the construction requirements for the clothing. The material must be certified in accordance with either EN or EN Classic heat stroke primarily occurs in individuals with immune dysfunction during heat waves each year 1 — 4.

Therefore, it is important to investigate the pathogeneses of heat stroke and develop effective preventive and treatment methods accordingly. The microcirculation mainly ensures that the oxygen supply to tissues is adequate 7. Microcirculation disorders usually present as decreased microvascular blood flow, damage to endothelial cells and high vascular permeability, lower microvascular reactivity, and leukocyte adhesion and migration. Studies have suggested that microcirculatory disorders are closely correlated with MODS and directly affect the prognosis of hemorrhagic or septic shock 8 , 9.

Oxygen free radicals produced in the interaction between the endothelium and leukocytes contributed to microcirculatory disorders in an ischemia—reperfusion model, similar to hemorrhagic shock A recent study also found that both pretreatment and post-treatment with anti-oxidants could attenuate microcirculation disorders 11 , In severe heat stroke, microcirculation disorders are inextricably associated with pathophysiological processes including circulatory failure, tissue edema, and bacterial translocation.

As reported in a previous study 13 , microcirculation disturbance occurs not only in the early stage but also before systemic hemodynamic disorders and manifests as reduced microvessel blood flow rate and increased water content and Evans blue concentration in lung tissue. Intervention with anti-oxidative agents [superoxide dismutase SOD ]may have certain protective effects in severe heat stroke.

Xuebijing injection is a traditional Chinese medicine approved by the China Food and Drug Administration for treating systemic inflammatory diseases, such as sepsis, acute lung injury ALI , and acute kidney injury. Xuebijing consists of extracts from five Chinese herbs: A recent report identified that some active ingredients in Xuebijing, including enkyunolide I, safflor yellow A, oxypaeoniflorin, and benzoylpaeoniflorin, inhibit the activity of nuclear factor kappa B, a key factor in inflammatory responses.

It was previously reported that Xuebijing inhibited inflammatory responses, attenuated liver injury, and improved survival rates in rats with heat stroke Xuebijing is likely a potential effective medicine in treating heatstroke, but studies that address the roles of Xuebijing in heat stroke are insufficient. Additionally, the roles of Xuebijing in microcirculatory disorders during heatstroke require further exploration. We hypothesize that Xuebijing is a protective agent that can attenuate microcirculation disorders during heat stroke by reducing ROS.

Therefore, in this study, we reproduced the classic severe heat stroke rat modeland evaluated SOD and ROS levels during heat stress HS , observed the changes in the microcirculation during heat stress, and investigated the role of oxidative stress in heat stroke by comparing the effects of SOD and Xuebijing during HS. SOD activity decreased gradually with the increase in the core temperature during heat stress compared with the control group.

The SOD activity in each group was measured using corresponding kits. Detection of ROS in spinotrapezius by flow cytometry. A The cell numbers were high, the density distribution was normal, and the results were reliable. Alterations in microcirculatory blood flow. The arteriolar and venular blood flow rates panels E and Panel F were calculated using the following formula: Changes in arteriolar diameter: Changes of venular diameter: The changes of venular diameter that occurred with the increase in the core temperature in the three groups were not significantly different during heat stress.

In addition, the venular diameter was not significantly different among the treatment groups Fig. Changes of arteriolar flow rate: Changes of venular flow rate: In addition, the average arterial pressure in this group also showed no evident decrease during heat stress.

Mean arterial pressure MAP.

Microcirculatory Disorders and Protective Role of Xuebijing in Severe Heat Stroke

Right femoral artery catheter was performed before heat stress, and mean arterial pressure MAP was observed continuously. The MAP of rats in the three groups was compared at different time points. However, the body mass loss in the three groups exposed to heat stress, but not the control group, was not significantly different at the same core temperature Fig. Changes of body mass. Heat stroke can be classified as classic heat stroke or exertional heat stroke according to the etiology 4. According to a previous study, severe heat shock was defined as follows in the present study: However, the spinotrapezius muscle and fascia were too thick in rats of this weight, and hence observing the microvessels with a microscope was extremely difficult.

However, the relatively low body weight of these rats also created another disadvantage in that their resistance to heat stress was also relatively low. The findings of this study showed that SOD activity decreased and the ROS level increased gradually in the spinotrapezius muscle of rats as the core temperature increased during heat stress. Recent studies have shown that SOD can relieve the inhibitory effects of superoxide on catecholamine, restore the reactivity of sympathetic vasoconstrictive agents, improve the symptoms of sepsis shock, maintain intracellular calcium homeostasis, improve mitochondrial functions, reduce oxygen radical damage, and restore homeostasis affected by shock 20 , Various animal models of shock have shown that the imbalanced oxidative stress response caused by decreased SOD activity is closely associated with multiple pathophysiological processes and microcirculation disturbance.

Supplying SOD can effectively reduce organ function damage during shock However, the ROS generation catalyzed by various enzyme systems is closely associated with endothelial dysfunction. The ROS generated by these enzyme systems can cause oxidative stress, thus inducing mitochondrial dysfunction, endothelial dysfunction, vascular adhesion molecule abnormalities, increased permeability, inflammatory mediator release, and finally organ dysfunction In our study, the changes in the oxidative stress level were closely associated with local microcirculation disturbances, such as decreased microvascular blood flow and abnormal vascular reactivity.

Supplying SOD to the rats effectively inhibited ROS generation during heat stress, thus improving the local microcirculation disturbances caused by oxidative stress. The findings of this study also demonstrated that the SOD activity increased gradually in the spinotrapezius of rats injected with Xuebijing, and Xuebijing injection also effectively decreased the ROS level in the local spinotrapezius tissues.

In this study, at the onset of heat stress, the MAP decreased significantly; this is likely because body fluid loss and the regulation of body fluid distribution in the early stage of heat stress can lead to a decrease in the effective circulating blood volume. The hemodynamic characteristics of heat shock are similar to those of hemorrhagic shock. Previous studies have shown that in the early phase of hemorrhagic shock, the microvessel V RBC and blood flow rate decrease In our study, when the rats were pretreated with Xuebijing or SOD, the V RBC and blood flow rate in microvessels were significantly better than those in the vehicle group, suggesting that Xuebijing could protect against the heat-stress-induced decrease in the blood flow rate in microvessels.

In this study, however, the changes in the arteriolar and venular diameters from the initiation of heat stress to the onset of severe heat stroke were not statistically significant.

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Previous studies on hemorrhagic stroke showed that the arteriolar and venular diameters decreased indicating microvessel contraction in hemorrhagic stroke It is known that during shock, the vasoconstriction of vessels of the skin favors the shifting of blood toward more crucial organs such as the heart, brain or liver. Nevertheless, a recently study demonstrated that maintenance of functional capillary density was the only critical microvascular parameter correlated with survival in severe hemorrhagic shock Thus, our findings further suggested that the decrease in the blood flow volume was mainly caused by the decrease in blood flow velocity in the microvessels in the period from the initiation of heat stress to the onset of severe heat stroke.

This study found that the MAP decreased in the early stage of heat stress. We speculated that the MAP decrease in this phase could be associated with self-regulation, such as the re-distribution of body fluid. However, the MAP was restored to the level observed before heat stress when the core temperature increased to This restoration could be associated with the occurrence of heat stress responses.

A side effect of this method of atmospheric re-entry is aerodynamic heating , which can be highly destructive to the structure of an unprotected or faulty spacecraft. Two basic types of aerodynamic heat shield have been used:. Passive cooled protectors are used to protect spaceships during atmospheric entry to absorb heat peaks and subsequently irradiate stored heat to the atmosphere. Early versions included a substantial amount of metals such as titanium , beryllium and copper.

This greatly increased the mass of the vehicle. Heat absorption and ablative systems became preferable.

Protective Heat Heat Series Book 3 - edelweiss.ml

In modern vehicles, however, they can be found, but instead of metal, Reinforced carbon—carbon material is used also called RCC Reinforced carbon-carbon or carbon-carbon. This material constitutes the thermal protection system of the nose and the front edges of the Space Shuttle and was proposed for the vehicle X These characteristics make it a material particularly suitable for passive cooling, but with the disadvantage of being very expensive and fragile.

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Some spacecraft also use a heat shield in the conventional automotive sense to protect fuel tanks and equipment from the heat produced by a large rocket engine. Heat shields are often affixed to semi-automatic or automatic rifles and shotguns as barrel shrouds in order to protect the user's hands from the heat caused by firing shots in rapid succession. They have also often been affixed to pump-action combat shotguns, allowing the soldier to grasp the barrel while using a bayonet.

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